Spray Dried Dispersions

Visualize and control particle microstructure to improve dissolution, stability, and manufacturability at every stage of development.

Tablet

Who this is for

Drug product and process development teams working on spray‑dried dispersions (SDDs) for tablets, capsules, granules, and DPIs, especially when scaling across sites or CDMOs.​

The Problem

SDD particles have complex, hollow morphologies that strongly influence dissolution, stability, tablet strength, and ultimately bioavailability and yield.​

Traditional tools cannot quantify these structures at scale, so teams only see the business impact as variability: failed dissolution tests, tablet defects, site‑to‑site differences, clinical surprises.

Business Outcomes

Less Variability
Reduce dissolution failures and batch-to-batch differences across sites
Lower Costs
Cut down troubleshooting and rework during scale up and tech transfer
Better CDMO Choices
More confidence in vendor selection and process robustness
Lower Clinical Risk
Fewer surprises tied to solubility and bioavailability

Our Solution: SDD Microstructure Insight Sprint

A defined 3 to 6 week engagment that combines 3D X-ray micro CT imaging and advanced AI analytics to:

What You Get

Microstructure to Performance Map
Which morphology attributes drive dissolution, mechanical strength, and stability
Proposed CPPs and scale up guidance
Anchored in actual SDD structures
Ranked list of SDD CQAs
With recommended control ranges tied to performance outcomes
Optional in-silico dissolution scenarios
For key formulations

Formulations

Studied

101
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Transform Your Program with Microstructure Science

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