dissoLab Particles

An in silico platform that models particle dissolution using size, shape, and microscopy images to enable predictive data-driven formulation decisions.

4K microstructure render of a DigiM pharmaceutical sample showing internal phase composition at high resolution
Full field-of-view pharmaceutical tablet microstructure image showing internal phase distribution and pore network
dissoLab Particles

Tackle Dissolution Challenges Early with In-Silico Precision

Particle dissolution is a critical factor influencing product performance across a wide range of dosage forms. In particular, non-micronized particles in BCS Class II and IV compounds often present challenges due to dissolution rate limitations. dissoLab empowers formulators with a cutting-edge, fully in-silico platform for accurately modeling and characterizing particle dissolution behavior. By simulating performance based on hypothetical particle size distributions, dissoLab enables users to make informed formulation and manufacturing decisions—well before physical synthesis begins. This predictive capability not only accelerates development timelines by reducing reliance on physical release testing, but also supports smarter, data-driven strategies for product optimization from the earliest stages of development.

A plot showing the dissolution release of 4 different drug particle formulations.
dissoLab Particles

Unlock the Full Potential of Dissolution Modeling with dissoLab

Microstructure plays a critical role in product development and performance, particularly in particle dissolution, where two key factors govern the dissolution rate: particle size and particle shape. While advanced modeling techniques have begun to incorporate particle size distributions for improved accuracy, most still fall short in effectively addressing particle shape. dissoLab bridges this gap. Our cutting-edge platform is the first of its kind to simultaneously account for both size and shape distributions, delivering an industry-leading solution for accurately tracking particle surface evolution throughout the dissolution process.

Upscaled FIB-SEM image 4 of a pharmaceutical sample showing cross-sectional material phases at nanoscale resolution

Transform Your Program with Microstructure Science

Get started with a drug product digital twin.

Purple tablet dispersing into a fine particle cloud, illustrating drug microstructure disintegration
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Merck logo
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Moderna logo
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Novartis logo
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Pfizer logo
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Johnson & Johnson Innovative Medicine logo
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Roche logo
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Mirati Therapeutics logo
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Genentech logo
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Lonza logo
Lonza logo
AbbVie logo
AbbVie logo
Bausch Health logo
Bausch Health logo
Bristol Myers Squibb logo
Bristol Myers Squibb logo
Merck logo
Merck logo
Moderna logo
Moderna logo
Novartis logo
Novartis logo
Pfizer logo
Pfizer logo
Johnson & Johnson Innovative Medicine logo
Johnson & Johnson Innovative Medicine logo
Roche logo
Roche logo
Mirati Therapeutics logo
Mirati Therapeutics logo
Genentech logo
Genentech logo
Lonza logo
Lonza logo