DigiM developed innovative technologies to predict release performance of monolithic implant without release test. Results and publications on this subject will be available in the very near future. 

Diffusion-Controlled Drug Delivery Systems.

Schematic presentation of: (a) a thin ointment film/matrix system containing finely dispersed drug and being exposed to perfect sink conditions and (b) the drug concentration-distance profiles within the film during drug release, considered for the derivation of the Higuchi equation.

DigiM image-based release model inspired by Juergen Siepmann, Ronald A. Siegel, and Florence Siepmann, 2012.

Reservoir devices with a nonconstant activity source: schematic presentation of the conditions for drug diffusion through the release-rate controlling membrane surrounding the drug reservoir. Stars indicate molecularly dispersed (dissolved) drug molecules; Cinner denotes the drug concentration at the inner membrane’s surface. The membrane thickness and permeability are considered to be time-independent.

Reservoir devices with a constant activity source: schematic presentation of the conditions for drug diffusion through the release-rate controlling membrane surrounding the drug reservoir. Stars indicate molecularly dispersed (dissolved) drug molecules, black circles represent nondissolved drug excess (e.g., drug crystals), and Cinner denotes the drug concentration at the inner membrane’s surface (saturation concentration) as long as drug excess is available.

The membrane thickness and permeability are considered to be time-independent.